Clinical Inquiries

Clinical Inquiries

Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD?

Author:

Vinay Reddy, MD

James Allison, MD

Anne Mounsey, MD

EVIDENCE-BASED REVIEW: YES. In patients with known cardio- vascular disease (CVD), ezetimibe with a statin decreases major adverse cardiovascular...

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Clinical Inquiries

Does hormone replacement therapy prevent cognitive decline in postmenopausal women?

Author:

Madeline Gates, MD

Melissa Beagle, MD, MPH

Lauren Bull, MD

Roxanne Radi, MD, MPH

Corey Lyon, DO

Kristen DeSanto, MSLS, MS, RD

EVIDENCE-BASED REVIEW: NO. Hormone replacement therapy (HRT) does not prevent cognitive decline in postmenopausal women—and in fact, it may...

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Clinical Inquiries

Should RAAS blockade therapy be continued in patients with advanced renal disease?

Author:

Kim Pham, DO

Carli Beyer, DO

EVIDENCE-BASED REVIEW: PROBABLY. Renin-angiotensin- aldosterone system (RAAS) blockade therapy should be continued in most patients with advanced...

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Clinical Inquiries

Should antenatal testing be performed in patients with a pre-pregnancy BMI ≥ 35?

Author:

Lee Dresang, MD

Lia Vellardita, MA

EVIDENCE-BASED REVIEW: Possibly. Elevated BMI is associated with an increased risk for stillbirth (strength of recommendation [SOR], B; cohort...

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Clinical Inquiries

Does regular walking improve lipid levels in adults?

Author:

Kayla Hatchell, MD

Emily Chin, DO

Brian Vukelic, MD

Katherine Fortenberry, PhD

Dominick Ose, DrPH

Eliza Taylor, MPH, BS, CHES

Rachel Goossen, MD

EVIDENCE-BASED ANSWER: Minimally. Regular moderate- intensity walking for a period of 4 or more weeks minimally decreased total cholesterol (TC)...

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Clinical Inquiries

Does physical exercise reduce dementia-associated agitation?

Author:

Katarzyna Jabbour, PharmD, BCPS

Lynn M. Wilson, DO, FACOFP, FAAFP

Susan S. Mathieu, MD

Drew Keister, MD, FAAFP

EVIDENCE-BASED ANSWER: Not consistently. Physical exer- cise demonstrates inconsistent benefit for neuropsychiatric symptoms, including agitation...

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Clinical Inquiries

How does gender-affirming hormone therapy affect QOL in transgender patients?

Author:

Sarah Wilhelm, MD

Gary Kelsberg, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: There are modest effects on depression but not anxiety. ­Gender-affirming hormone therapy (GAHT) is associated with modest...

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Clinical Inquiries

How accurate is transcutaneous bilirubin testing in newborns with darker skin tones?

Author:

Brandi Boden, DO

Brittany Buescher, MD

Amanda Kim, MD

Jon O. Neher, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Fairly accurate. Photometric transcutaneous bilirubin (TcB) testing may overestimate total serum bilirubin (TSB) in...

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Clinical Inquiries

Does an early COPD diagnosis improve long-term outcomes?

Author:

Dan Bernet, MD

Charles Randolph, MD

Jon O. Neher, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: It depends. A diagnosis of chronic obstructive pulmonary disease (COPD) made using screening spirometry in patients without...

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Clinical Inquiries

What barriers delay treatment in patients with hepatitis C?

Author:

Kimberly Crosby, PharmD

Simone Bigelow, DO

Viviane Sachs, MD

Jennifer Weakley, MD

Helga Skaftason, MD, MPH

Toni Hoberecht, MA, MLIS, AHIP

EVIDENCE-BASED ANSWER: Multiple patient-specific and provider-perceived factors delay initiation of treatment in patients with hepatitis C....

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Clinical Inquiries

Do behavioral interventions improve nighttime sleep in children < 1 year old?

Author:

Morgan Hungenberg, DO

Breanna Houss, MD

Madhav Narayan, MD

Corey Lyon, DO

Kristen DeSanto, MSLS, MS, RD

EVIDENCE-BASED ANSWER: YES. Infants respond to behavioral interventions, although objective data are limited. Behavioral interventions include...

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