The large spherules (10–80 mcm) of Coccidioides are easily seen under microscopy, typically as granulomatous or suppurative inflammatory infiltrate. If needed, an in situ hybridization assay is available to distinguish the organism from Blastomyces or Cryptococcus.
Patients with coccidioidomycosis generally are managed by primary care physicians or infectious disease specialists.
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Sweet's syndrome, presenting as painful plaques, are associated with pulmonary coccidioidomycosis. Courtesy Dr. David J. DiCaudo