The ADAS-cog focuses on psychomotor speed and attention tests. Analysis of the ADAS-cog favored the donepezil group, with 22.3% showing a ≥7-point score vs 12.1% in the placebo group. There were no significant differences on the PGA in the intention-to-treat analysis.8 The donepezil group had a higher rate of adverse drug reactions (P<.03) including diarrhea, nausea, vomiting, leg cramps, and abnormal dreams. The discontinuation rate was 22% in the donepezil group compared with 8% in the placebo group (number needed to harm=7).8
Recommendations from others
We found no recommendations about using cholinesterase inhibitors in mild cognitive impairment.