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Quick drug interventions didn’t help long-term abuse

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In drug intervention, timing is everything

Despite a few small methodological weaknesses, these studies sharply point out a real need for effective drug abuse interventions in primary care, Ralph Hingson, Sc.D., and Dr. Wilson M. Compton wrote in an accompanying editorial (JAMA 2014;312:488-9).

"Although these studies offer no direct evidence of effectiveness for universal drug screening, brief intervention, and referral to treatment in primary care settings, exploring drug use with patients should remain a priority in primary care," wrote Dr. Hingson and his coauthor.

The studies are well designed and well executed, but not perfect, the team noted. "Neither study analyzed alcohol or tobacco as the primary drug of abuse or measured simultaneous same-day alcohol/drug use or drug/drug use, and both samples had high rates of physical and mental health comorbidity" and socioeconomic issues.

The authors also noted that the study by Dr. Roy-Byrne had limited complete follow-up data, with only 46% of the cohort participating in the booster.

One reason for the negative findings may be timing, they said. Substance abuse nearly always starts in youth; by the time a patient reaches the third or fourth decade, a difficult-to-break behavior has emerged. And ignoring the threat posed by simultaneously abusing multiple substances addresses only a limited aspect of the issue.

"Research indicates that more people begin combined use of alcohol, tobacco, and drugs in adolescence than begin use of any single substance. Multiple substance initiators experience a greater likelihood they will develop dependence on multiple substances. Drugs, alcohol, and tobacco use by youth each stimulate brain reward for the other substances, supporting the idea that each is a gateway for the use of the other substances," Dr. Hingson and Dr. Compton noted.

The authors called for more research, not only for adults in primary care, but also for special populations and settings: during pregnancy; in trauma centers, mental health clinics, and college, military, and employment settings; and in programs for intoxicated drivers.

"If brief interventions are insufficient, then easily accessible treatment services with long-term follow-up may be needed, as will the development of efficient primary care referral approaches to address risk substance use and related physical and mental comorbidities," they wrote.

Dr. Hingson is director of epidemiology and prevention research at the National Institute on Alcohol Abuse and Alcoholism. Dr. Compton is deputy director of the National Institute on Drug Abuse. Neither reported any financial disclosures.


 

FROM JAMA

References

Refer, then follow up

Both studies’ findings are not surprising, Dr. Peter D. Friedmann said in an interview.

"Drugs are much more reinforcing than alcohol or tobacco, and so are their effects on behavior," said Dr. Friedmann, an internist at the Providence (R.I.) Veterans Affairs Medical Center. "This makes it much more difficult to extinguish drug use and its associated behaviors; that needs much more than just a brief counseling intervention."

Patients struggling with substance abuse need – and deserve – more than such a brief addressing of their problem, said Dr. Friedmann, also professor of health services, policy, and practice at Brown University, also in Providence. Medical treatment is a good first step and feasible for a primary care physician to administer in the office. Unfortunately, such treatment is only available for opiate misuse.

Extensive counseling, however, is beyond the purview of these doctors, he said, so expert referral with follow-up is a must.

"But we can’t simply refer and say, ‘Come back to me in 2 or 3 months, and we’ll see where you are.’ If we refer someone to a cardiologist, we follow up, we make sure the patient got there, and we expect a note back from the cardiologist," Dr. Friedmann said. "That doesn’t happen with drug referrals."

Dr. Friedmann acknowledged that there is scant literature supporting this kind of primary care. But that doesn’t mean it’s not helpful, or that it shouldn’t be done, he said.

"We do a lot of things in medicine for which there is no randomized, controlled evidence of effect. We do it because it’s our professional duty," he explained. "If we are confronted with someone who is struggling with this problem, even if it’s hard to find the evidence, it is part of our obligation to help."

The National Institute on Drug Abuse sponsored Dr. Roy-Byrne’s study. He had no financial disclosures, although several of his coauthors reported relationships with pharmaceutical companies. NIDA also supported Dr. Saitz’s study; he had no relevant disclosures.

Dr. Friedmann disclosed that he has received research support (medication only) from Alkermes and has been a speaker for Orexo.

msullivan@frontlinemedcom.com

On Twitter @alz_gal

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