The investigators designed the study to shed some light on AGUs, as the available literature is limited, and many providers may not be familiar with the evaluation and management of patients with AGUs, they said.
The findings demonstrate that AGUs occur most often in postmenarcheal adolescents vs. premenarcheal adolescents. Most cases in this series were preceded by 3 days of febrile viral illness and were associated with elevated inflammatory markers. Only six had an infectious etiology identified, and those patients had acute mononucleosis infection.
Of note, two patients developed complications of labial fusion during healing requiring surgical separation.
A third had a past history of oral aphthous ulcers, and 10 had concurrent oral aphthous ulcers, suggesting a diagnosis of complex aphthosis, they said.
Recurrences most often occurred in the setting of febrile viral illness, physical exhaustion, or emotional stress.
The authors reported having no relevant financial disclosures.