ALL
Conference Coverage
Predicting outcomes of allo-HSCT in ALL
Photo by Chad McNeeley SAN DIEGO—A retrospective study has revealed a few factors that may predict outcomes of allogeneic hematopoietic stem cell...
News
Approved TKI could treat drug-resistant CML, ALL
Photo courtesy of CDC New research indicates that a tyrosine kinase inhibitor (TKI) approved to treat advanced renal cell carcinoma could prove...
News
Gene variation explains drug toxicity in ALL
Credit: Peter Barta Inherited variations in the NUDT15 gene can reduce tolerance of the drug mercaptopurine in children with acute lymphoblastic...
News
Fusion protein fights resistant ALL
In a preclinical study, a fusion protein targeted treatment-resistant leukemia, demonstrating superiority over both chemotherapy and radiation....
News
EC supports continued use of ponatinib
Credit: Rhoda Baer The European Commission (EC) has concluded that ponatinib (Iclusig) should continue to be prescribed in accordance with its...
Conference Coverage
CARs come in different makes and models
Credit: NIAID SAN FRANCISCO—CTL019, a chimeric antigen receptor (CAR) T cell targeting CD19, is not the only CAR in the production line....
Conference Coverage
CAR is feasible in majority of ALL patients, team says
Credit: Bill Branson SAN FRANCISCO—A chimeric antigen receptor (CAR) T-cell therapy is feasible in 90% of heavily pretreated or transplanted...
Conference Coverage
CAR produces durable responses in B-cell ALL
Credit: Charles Haymond SAN FRANCISCO—JCAR015, a chimeric antigen receptor (CAR) T-cell therapy, can produce durable responses in patients with B...
Conference Coverage
CAR-T cell therapy rolls on in pediatric ALL
Key clinical point: CAR-T cell therapy continues to provide durable responses in early studies of children with refractory ALL. Major finding:...
Conference Coverage
Blinatumomab confirmed as treatment option in MRD+ ALL
SAN FRANCISCO—The first international, multicenter trial in acute lymphoblastic leukemia (ALL) using minimal residual disease (MRD) as a criterion...
Conference Coverage
Researchers show CTL019 cells proliferate and persist
Researchers at the University of Pennsylvania, working with CTL019 cells, are beginning to see both of these phenomena in children with relapsed,...