Clinical Edge Journal Scan

Bone marrow cells contribute to AML disease environment


 

Key clinical point: Bone marrow stromal cells in patients with myelodysplastic syndromes and acute myeloid leukemia showed a reduced frequency of colony forming unit-fibroblasts.

Major finding: The frequencies of positive/positive bone marrow stromal cells were significantly lower in AML patient samples compared to healthy individuals and MDS bone marrow samples. The median cell numbers of bone marrow stromal cells in diagnostic samples were 3,200 for healthy samples, 476 for MDS samples, and 70 for AML samples.

Study details: The data come from bone marrow samples in AML patients, MDS patients, and healthy donors.

Disclosures: The study was supported in part by Projekt DEAL and the Deutsche Forschungsgemeinschaft SFB 1243 for projects A09 and the FOR2033 project B3, as well as the Deutsche Jose Carreras Leukämie Stiftung. The researchers had no financial conflicts to disclose.

Source: Weickert M-T et al. Sci Rep. 2021 Mar 15. doi: 10.1038/s41598-021-85122-8.

Recommended Reading

Omidubicel improves on umbilical cord blood transplants
MDedge Hematology and Oncology
Risk factors predict graft failure in pediatric acute leukemia patients
MDedge Hematology and Oncology
Rural AML patients fare as well as urban patients for survival and treatment
MDedge Hematology and Oncology
Early tumor cell response predicts AML treatment success
MDedge Hematology and Oncology
Green tea extract promotes immune system function in older AML patients
MDedge Hematology and Oncology
Venetoclax succeeds for AML remission in untreated older patients
MDedge Hematology and Oncology
Glasdegib and venetoclax show similar success for AML
MDedge Hematology and Oncology
Gene mutation status impacts overall survival in acute myeloid leukemia
MDedge Hematology and Oncology
Loss of tumor suppressor may drive cytarabine resistance in AML
MDedge Hematology and Oncology
Transfusion reliance remains after AML treatment with VEN and HMA
MDedge Hematology and Oncology