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Eczema may increase lymphoma risk, cohort studies suggest

Key clinical point: Atopic eczema was associated with a heightened risk of lymphoma, especially non-Hodgkin lymphoma.

Major finding: Adjusted hazard ratios for non-Hodgkin lymphoma in the English cohort were 1.06 (99% confidence interval, 0.90-1.25) for mild atopic eczema, 1.24 (99% CI, 1.04-1.48) for moderate eczema, and 2.08 (99% CI, 1.42-3.04) for severe eczema.

Study details: Two large matched cohort studies conducted from 1998 to 2016 in England and Denmark.

Disclosures: Partial support was provided by the Wellcome Trust, the Royal Society, the Dagmar Marshalls Fund, and the Aase and Ejnar Danielsens Fund. Dr. Mansfield disclosed support from a Wellcome Trust grant. Her coinvestigators disclosed ties to TARGET-DERM, Pfizer, and GlaxoSmithKline, and from the Wellcome Trust, Medical Research Council, the National Institute for Health Research, the British Heart Foundation, Diabetes UK, and IMI Horizon 2020 funding BIOMAP.

Citation:

Mansfield KE et al. JAMA Dermatol. 2020 Jun 24. doi: 10.1001/jamadermatol.2020.1948.