Key clinical point: Men with genetic variants that cause hereditary hemochromatosis have an increased risk of liver cancer and death, according to a large cohort study.

Major finding: The risk of primary hepatic malignancy (hazard ratio, 10.5; P < .001) and the risk of all-cause death (HR, 1.2; P = .046) were significantly higher in men with HFE p.C282Y homozygosity, compared with men without HFE pathogenic variants. There were no significant associations in women.

Study details: A cohort study of 451,186 UK Biobank participants of European ancestry, aged 40-70 years.

Disclosures: This research was funded by the UK Medical Research Council. One author disclosed financial affiliations with the UK Medical Research Council during the conduct of the study.