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Luspatercept reduced transfusion burden in trial

List AF et al. ASH 2018, abstract 1

Key clinical point: Luspatercept, a novel erythroid maturation agent, significantly reduced transfusion burden versus placebo in patients with anemia caused by myelodysplastic syndromes and ringed sideroblasts.

Major finding: The proportion of patients achieving RBC transfusion independence for at least 8 weeks during the first 24 weeks of treatment was 37.9% for luspatercept and 13.2% for placebo (P less than .0001).

Study details: A randomized, phase 3 trial including 220 lower-risk myelodysplastic syndromes patients with ringed sideroblasts who were RBC transfusion–dependent.

Disclosures: Dr. List reported research funding from Celgene.

Read the article here.

Citation:

List AF et al. ASH 2018, abstract 1.