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Air Pollution and Breast Cancer Risk

Probing possible associations

Publish date:: November 17, 2015

No significant associations between air pollution and breast cancer risk overall were seen in a study of 47,591 women, including 1,749 in whom invasive breast cancer arose during a 10-year period. Researchers found:

• Overall, breast cancer risk was not associated with exposure to fine particulate matter or to nitrogen dioxide (NO₂).

• However, the association with NO₂ differed according to estrogen receptor(ER)/ progesterone receptor subtype.

• For an interquartile range difference of 5.8 parts per billion NO₂, the relative risk of ER⁺/PR⁺ breast cancer was 1.10, though there was no evidence of association with ER^-/PR^-.

Citation: Reding KW, Young MT, Szpiro AA, et al. Breast cancer risk in relation to ambient air pollution exposure at residences in the Sister Study cohort. [Published online ahead of print October 13, 2015]. Cancer Epidemiol Biomarkers Prev. doi: 10.1158/1055-9965.EPI-15-0787.

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