Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Obinutuzumab plus venetoclax compares well with established CLL therapies
Cramer P et al. Lancet Oncol. 2018 Aug 13. doi: 10.1016/S1470-2045(18)30414-5.
Key clinical point: Obinutuzumab plus venetoclax show significant efficacy in patients with chronic lymphocytic leukemia.
Major finding: The overall response rate for obinutuzumab plus venetoclax in CLL was 95%.
Study details: An ongoing, phase 2, open-label trial in 66 patients with chronic lymphocytic leukemia.
Disclosures: The study was funded by F Hoffmann-La Roche and AbbVie. Several authors reported research funding, grants, honoraria, and other support from the pharmaceutical industry, including from the study sponsors.
Citation:
Cramer P et al. Lancet Oncol. 2018 Aug 13. doi: 10.1016/S1470-2045(18)30414-5.