Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Link Between Vitamin D and Lymphoma Survival

Analysis of patients in SWOG and LYSA trials

Publish date:: April 14, 2015

Serum vitamin D levels may be a potentially modifiable factor associated with survival in follicular lymphoma (FL), according to an analysis of two cohort studies of patients with previously untreated FL.

Using baseline serum samples of 25-hydroxyvitamin D, investigators analyzed the adjusted progression-free survival (PFS) hazard ratio (HR) and overall survival HR for patients in SWOG and Lymphoma Study Association (LYSA) trials. In patients who were vitamin D deficient (<20 ng/mL in SWOG or <10 ng/mL in LYSA), the following PFS and overall survival HRs were as follows:

	PFS	Survival
SWOG	1.97	4.16
LYSA	1.50	1.92

Citation: Kelly JL, Salles G, Goldman B, et al. Low serum vitamin D levels are associated with inferior survival in follicular lymphoma: a prospective evaluation in SWOG and LYSA studies. J Clin Oncol. 2015. pii: JCO.2014.57.5092.

This Week's Must Reads

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Mortality risks rise with age, infections, but not inhibitor status in persons with non-severe hemophilia A,

‘Impressive’ local control with MRI-guided brachytherapy in cervical cancer,

U.S. mothers underestimate role breastfeeding plays in curbing breast cancer,

Must Reads in Follicular Lymphoma

Survey quantifies COVID-19’s impact on oncology,

Adding lymphopenia component ‘improves’ FLIPI,

REGN1979 shows good activity in pretreated aggressive B-NHL,

Survival Data Reported From Largest CAR T Trial in B-Cell Lymphoma,

Newly identified genetic changes contribute to transformation of follicular lymphoma,