Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Limited Resection in Lung Cancer

How does it compare with lobectomy?

Publish date:: August 11, 2015

Limited resection is not equivalent to lobectomy in patients older than 65 years with invasive non–small-cell lung cancer ≤ 2 cm in size, although segmentectomy may be equivalent in patients with adenocarcinoma (ACA), according to a study of 2,008 patients with ACA and 1,139 with squamous cell carcinoma (SCC). Researchers found:

• Overall, 27% of patients with ACA and 32% of patients with SCC underwent limited resection.

• Survival analysis showed that limited resection was not equivalent to patients with ACA [hazard ratio (HR), 1.21] or SCC [HR, 1.21].

• Patients with ACA treated with segmentectomy had equivalent survival rates to those treated with lobectomy (HR, 0.97), while those treated with wedge resection had lower rates (HR, 1.29).

• Among patients with SCC, neither wedge resection (HR, 1.34) nor segmentectomy (HR, 1.19) were equivalent to lobectomy.

Citation: Veluswamy RR, Ezer N, Mhango G, et al. Limited resection versus lobectomy for older patients with early-stage lung cancer: impact of histology. [Published online ahead of print August 3, 2015]. J Clin Oncol. doi: 10.1200/JCO.2014.60.6624.

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