Solid predominant subtype is an independent predictor of early recurrence and, among those patients who recur, of worse postrecurrence survival (PRS), according to a study of 1,120 patients with stage I lung adenocarcinoma who underwent complete surgical resection. Researchers found:

• Of 1,120 patients, 188 had recurrent disease, 103 of whom died of lung cancer.

• Among patients who recurred, 2-year PRS was 45%, with median PRS of 26.1 months.

• Compared with patients with nonsolid tumors, patients with solid predominant tumors had recurrences that were earlier, more extrathoracic, and more multsite.

• Among patients who recurred, a worse PRS was associated with solid predominant histologic pattern in the primary tumor, age > 65 years, and sublobar resection.

• Also significantly associated with worse PRS were extrathoracic metastasis and age > 65 years at recurrence.

Citation: Ujiie H, Kadota K, Chaft JE, et al. Solid predominant histologic subtype in resected stage I lung adenocarcinoma is an independent predictor of early, extrathoracic, multisite recurrence and of poor postrecurrence survival. [Published online ahead of print August 10, 2015]. J Clin Oncol. doi:10.1200/JCO.2015.60.9818.