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MCL in First Remission: Does Imaging Matter?
Leuk Lymphoma; ePub 2017 Aug 10; Guidot, et al
Surveillance imaging after first-line therapy was not linked with improved survival in patients with mantle cell lymphoma (MCL), according to a retrospective cohort study involving 217 individuals. Participants were from 2 academic institutions and completed first-line therapy for MCL. Investigators looked at surveillance imaging’s impact on survival. Among the results:
- 102 patients relapsed.
- 37% were diagnosed by surveillance imaging.
- Diagnosing relapse via surveillance imaging did not significantly impact overall survival from diagnosis date or relapse date.
- PET/CT had a positive predictive value of 24%, and number needed-to-scan/treat of 51 to detect 1 relapse.
- For CT, these numbers were 49% and 24, respectively.
Citation:
Guidot D, Switchenko J, Nastoupil L, et al. Surveillance imaging in mantle cell lymphoma in first remission lacks clinical utility. [Published online ahead of print August 10, 2017]. Leuk Lymphoma. doi:10.1080/10428194.2017.1361032.