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Phase 1 study shows feasibility, safety, efficacy of STAR T cells for ALL
Key clinical point: A phase 1 first-in-human study demonstrated synthetic T-cell receptor and antigen receptor technical feasibility, clinical safety and efficacy in treating CD19+ relapsed/refractory B-cell acute lymphoblastic leukemia.
Major finding: On day 14 following transplant, 100% had achieved a minimal residual disease–negative complete response/CR with incomplete hematologic recovery.
Study details: The first-in-human study included 18 CD19+ relapsed/refractory B-cell acute lymphoblastic leukemia patients, with a median bone marrow blast level pre–CAR T of 15.3% (0.5-90.5%).
Disclosures: Dr. Lu reported having no relevant conflicts of interest.
Lu P et al. ASH 2020, Abstract 270.