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Family Histories and Multiple Myeloma

Associations with discordant cancers

Publish date:: October 14, 2015

All the associations of multiple myeloma (MM) with discordant cancers are novel, suggesting that MM shares genetic susceptibility with many cancers, according to a study of 24,137 patients with MM. Researchers found:

• MM was reliably associated with relative’s colorectal, breast, and prostate cancers, nonthyroid endocrine tumors, leukemia, and cancer of unknown primary.

• MM was also associated with subsites of bone and connective tissue tumors and of non-Hodgkin lymphoma, including lymphoplamacytic lymphoma/Waldenstrӧm macroglobulinema.

• MM had a strong association in colorectal cancer families, perhaps as part of an unidentified syndrome.

Citation: Frank C, Fallah M, Chen T, et al. Search for familial clustering of multiple myeloma with any cancer. [Published online ahead of print October 9, 2015]. Leukemia. doi: 10.1038/leu.2015.279.

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