Key clinical point: An antibiotic-eluting envelope significantly reduced the risk of infection with CIED implantation.

Major finding: Antibiotic-eluting envelope in CIED implantation is associated with a 40% reduction in the risk of infection.

Study details: Randomized trial in 6983 patients.

Disclosures: The study was supported by Medtronic. Twenty-four authors declared institutional funding or research grants from Medtronic, thirteen declared fees, consultancies and other support from private industry outside the submitted work. Three authors were employees of Medtronic.