Key clinical point: Clinical, demographic, and genetic data could help risk-stratify patients with Lynch syndrome who should undergo enhanced surveillance for gastric cancer.

Major finding: Individuals with Lynch syndrome mutations were significantly more likely to have gastric cancer if they were older, male, had a first-degree relative with gastric cancer, or had pathogenic variants in MLH1 or MSH2.

Study details: Cross-sectional study of 51,086 individuals tested for gene variants associated with Lynch syndrome.

Disclosures: The National Institutes of Health and the Pussycat Foundation Helen Gurley Brown Presidential Initiative provided funding. One coinvestigator disclosed a consulting relationship with Myriad Genetic Laboratories and having rights to an inventor portion of licensing revenues from PREMM5, a prediction model for Lynch syndrome mutations. The other researchers reported having no conflicts of interest.