Key clinical point: Long noncoding ribonucleic acid (lncRNA) H19 and 10-11 translocation enzyme 1 ( TET1) messenger RNA expression levels showed high diagnostic and predictive values for determining postoperative recurrence of uterine fibroids (UFs).
Major finding: lncRNA H19 ( P = .010) and TET1 ( P = .014) levels independently predicted UF recurrence. The area under the curve values of lncRNA H19 and TET1 for predicting UF recurrence were 0.814 (sensitivity, 81.13%; specificity, 77.27%) and 0.765 (sensitivity, 69.81%; specificity, 77.27%), respectively.
Study details: This study enrolled 75 patients with UFs who underwent surgical treatment and 60 healthy controls. Patients with UF were followed up for 2 years to evaluate postoperative recurrence of UFs.
Disclosures: No information on funding was available. The authors declared no conflict of interests.
Source: Zhan X et al. Clinics. 2021 Sep 28. doi: 10.6061/clinics/2021/e2671.