Clinical Edge | MDedge Psychiatry

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

MDD: Modest improvements in female sexual functioning with adjunctive brexpiprazole,

Transcranial direct current stimulation not clinically relevant in MDD,

Interleukin-1 β and TNF-α hamper antidepressant response in MDD,

Impact of pimavanserin on anxious depression in patients with MDD,

Prior MDD moderates the association between endothelin-1 and post-ACS depressive symptoms,

FDA Actions

FDA Approves Cassipa for Opioid Addiction Treatment , FDA news release; 2018 Sep 7

FDA Approves Marketing of OCD Treatment Device, FDA Web site; 2018 Aug 17

Read more in FDA Actions

Somatic Disorders

Bipolar Disorder Linked with More Somatic Symptoms, J Affect Disord; ePub 2016 Jun 14; Edgcomb, Tseng, et al

Read more in Somatic Disorders

Sleep Medicine

Study links sleep meds and dementia risk in older adults,

Study validates OSA phenotypes in Latinos,

Read more in Sleep Medicine

Mixed Topics

Phase 1 study: Beta-blocker may improve melanoma treatment response,

Psychosocial resilience associated with better cardiovascular health in Blacks,

Read more in Mixed Topics

Sleep Medicine

Study links sleep meds and dementia risk in older adults,

Study validates OSA phenotypes in Latinos,

Read more in Sleep Medicine

Somatic Disorders

Bipolar Disorder Linked with More Somatic Symptoms, J Affect Disord; ePub 2016 Jun 14; Edgcomb, Tseng, et al

Read more in Somatic Disorders

Mixed Topics

Phase 1 study: Beta-blocker may improve melanoma treatment response,

Psychosocial resilience associated with better cardiovascular health in Blacks,

Read more in Mixed Topics

Major Depressive Disorder

MDD: Modest improvements in female sexual functioning with adjunctive brexpiprazole,

Transcranial direct current stimulation not clinically relevant in MDD,

Read more in Major Depressive Disorder

COVID-19 Updates

COVID-19 vaccine found effective but doctors watching for reactions, adverse events,

Obesity, hypoxia predict severity in children with COVID-19,

Read more in COVID-19 Updates

Major Depressive Disorder

MDD: Modest improvements in female sexual functioning with adjunctive brexpiprazole,

Transcranial direct current stimulation not clinically relevant in MDD,

Read more in Major Depressive Disorder

Obsessive-Compulsive Disorder

Deep transcranial magnetic stimulation alleviates OCD symptoms,

Ketamine may rely on opioid receptors for antidepressive effect,

Read more in Obsessive-Compulsive Disorder

Personality Disorders

Borderline Personality and Identity Disturbance, Psychiatry Res; ePub 2018 Nov 10; Gad, et al

Personality Inventory Aids Discerning BD from BPD , J Affect Disord; ePub 2018 Nov 13; Fowler, et al

Read more in Personality Disorders

Schizophrenia & Other Psychotic Disorders

Risk factors for QTc prolongation during amisulpride therapy in schizophrenia,

Schizophrenia: Reinitiating clozapine can be considered in patients who have previously discontinued it,

Read more in Schizophrenia & Other Psychotic Disorders

PTSD

One-fifth of stem cell transplantation patients develop PTSD,

Posttraumatic stress may persist up to 9 months after pregnancy loss,

Read more in PTSD

Addiction Medicine

E-cigarette use tied to increased COPD, asthma risk,

National lung cancer screening guidelines may miss younger African American individuals at high risk,

Read more in Addiction Medicine

Pediatrics

Rap music mention of mental health topics more than doubles,

Obesity, hypoxia predict severity in children with COVID-19,

Read more in Pediatrics

All Specialties