Key clinical point: Roux-en-Y gastric bypass (RYGB) correlated with greater reduction in areal bone mineral density (aBMD) and greater increase in bone turnover markers vs. sleeve gastrectomy (SG).
Major finding: From baseline to 1 year, aBMD in femoral neck, total hip, and lumbar spine decreased significantly more after RYGB than after SG (mean [95% confidence interval] between group differences: −2.8% [−0.8% to −4.7%], −3.0% [−0.9% to −5.0%], and −4.2% [−2.1% to −6.4%], respectively). The increase in procollagen type 1 N-terminal propeptide and C telopeptide of type I collagen was significantly higher after RYGB vs. SG ( P less than .001).
Study details: This randomized, triple-blind, single-center trial included 109 patients with severe obesity and type 2 diabetes randomly assigned (1:1) to RYGB (n = 54) or SG (n = 55).
Disclosures: The study was funded by the Morbid Obesity Center, Vestfold Hospital Trust. F Fatima received an educational grant (PhD) from South-Eastern Norway Regional Health Authority. Other authors had nothing to disclose.
Source: Hofsø D et al. J Clin Endocrinol Metab. 2020 Nov 5. doi: 10.1210/clinem/dgaa808 .