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Serum Uric Acid Regulation in Mexican Americans

BMC Genomics; 2016 Apr 2; Chiittor, Kent, et al

Publish date:: April 18, 2016

Chromosome 3p26 locus and genetic variants in this region play an important role in the regulation of serum uric acid concentrations, according to a study of genome-wide single nucleotide polymorphism data from 1,281 Mexican Americans from multigenerational families. Researchers found:

• Univariate genetic analysis showed serum uric acid concentrations to be significantly heritable.

• Linkage analysis of serum uric acid concentrations confirmed previous findings of a novel locus on 3p26.

• Strong associations of serum uric acid concentrations were seen with variants in the following candidate genes in the 3p26 region: inositol 1,4,5-triphosphate receptor, type 1 (ITPR1); contactin 4 (CNTN4); decapping mRNA 1A (DCP1A); transglutaminase 4 (TGM4); and rho guanine nucleotide exchange factor (GEF) 26 (ARHGEF26); and evidence of cis-regulation for ITPR1 transcripts.

Citation: Chittor G, Kent JW Jr, Almeida M, et al. GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans. BMC Genomics. 2016;17(1):276. doi:10.1186/s12864-016-2594-5.

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