Statistical Analysis
To assess similarity between weekend and weekday admissions, we used the Fisher exact test and χ2P values. Logistic regression was used to calculate the odds ratios (ORs) of mortality and perioperative complications for weekend versus weekday admissions. Linear regression was used to calculate parameter estimates for length of hospital stay for weekend versus weekday admissions. We interpreted parameter estimates as percentage differences using the formula 100(eb–1), where b is the estimated standardized regression coefficient of a log-transformed outcome variable.19 All regression models were controlled for age, sex, race, insurance, number of comorbidities, fracture location, hospital region, hospital bed size, hospital teaching status, and hospital location. We also stratified our study population by surgical delay in hours (<24, 24-48, 49-72, 73-120, ≥121) and by surgery performed (ORIF, hemiarthroplasty, CRIF, internal fixation only, THA, multiple procedures) to examine the effect of weekend admission on mortality, perioperative complications, and length of stay within each stratum. We did not control for these variables in our regression models because they were potential mediators of mortality, complications, and length of stay. All statistical analyses in this study were performed using SAS Version 9.1 (SAS Institute), and P < .05 was interpreted as statistically significant.
Results
After exclusions, our study population consisted of 96,892 weekend admissions and 248,097 weekday admissions. Among all admissions, mean age was 79.3 years (range, 0-113 years), with patients primarily being female and white, paying with Medicare, and having 1 to 4 comorbidities. Admissions were primarily for extracapsular femoral neck fractures and occurred most often in the South region, in hospitals with large beds, in nonteaching hospitals, and in urban locations. Table 1 lists details of baseline characteristics for weekend and weekday admissions.
Hospital stay details, including surgical delay and procedure performed, were examined for weekend and weekday admissions. Mean delay to surgery was 31.0 hours for weekend admissions and 30.2 hours for weekday admissions (P < .0001). The difference was driven by a higher proportion of weekend admissions in which surgery was performed 24 to 120 hours after admission. Patients admitted on the weekend also underwent more ORIF procedures and fewer hemiarthroplasties. Table 2 is a full list of hospital stay characteristics.
In regression analyses, weekend OR of mortality was 0.94 (95% CI, 0.89-0.99), weekend OR of having at least 1 complication was 1.00 (95% CI, 0.98-1.02), and weekend mean hospital stay was 3.74% shorter (95% CI, 3.40-4.08) in comparison with weekday figures. Within our models, risk of mortality and complications and mean length of stay increased as the number of patient comorbidities increased. Table 3 lists selected results from our regression models. Comprehensive tables for each outcome’s model are presented in Appendices 1 to 3.
In our analyses of specific complications, there were no significant associations between weekend admissions and risk of acute renal failure, wound hemorrhage, wound disruption, wound infection, deep vein thrombosis, myocardial infarction, pneumonia, pulmonary embolism, sepsis, urinary tract infection, implant infection, or incision and débridement. In addition, we found a lower risk of tachycardia (OR, 0.90; 95% CI, 0.82-1.00) and a higher risk (P < .10) of stroke (OR, 1.16; 95% CI, 0.99-1.35). Table 4 is a full list of the specific complications and their risks for weekend versus weekday admissions.
According to stratified analyses involving surgical delay, weekend admissions in which patients had surgery the same day as admission had decreased risk of mortality (OR, 0.81; 95% CI, 0.72-0.91) and perioperative complications (OR, 0.96; 95% CI, 0.92-0.99). In addition, hospital stay was shorter for weekend admissions with surgical delay of less than 24 hours (4.89% shorter; 95% CI, 4.22-5.55), 24 to 48 hours (5.93% shorter; 95% CI, 5.51-6.35), and 49 to 72 hours (3.50% shorter; 95% CI, 2.80-4.20). When admissions were stratified by procedure performed, patients who were admitted on the weekend and underwent ORIF, hemiarthroplasty, CRIF, internal fixation only, and THA had shorter stays than patients admitted on weekdays. For all surgeries performed, the risk of both mortality and complications did not significantly differ by day of admission. Table 5 lists the comprehensive results of all our stratified analyses.
Discussion
In this large, multiyear analysis of patients admitted for hip fracture in the United States, risk of mortality was slightly lower for weekend versus weekday admissions, hospital stay was significantly shorter, and risk of perioperative complications was not significantly different between admission types. In secondary analyses, shorter hospital stay was limited to patients who were admitted on weekends and underwent surgery within 48 hours. Our results therefore suggest that the weekend effect does not apply to hip fracture patients in the United States.