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‘Astonishing’ results: Skip salvage chemo, proceed to HSCT
New research on treating acute myeloid leukemia suggested that some patients may safely go straight to stem cell transplantation.
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Oral SERD camizestrant prolongs PFS vs. fulvestrant in breast cancer
The investigational selective estrogen receptor degrader showed efficacy in advanced ER+/HER2– breast cancers, including patients with ESR1...
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Chemotherapy meets its match against aggressive ER+/HER2– breast cancers
Ribociclib plus endocrine therapy resulted in high response rates and double progression-free survival over combo chemotherapy.
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Potential cause of worse outcomes among Black breast cancer patients found
Tumor microenvironment of metastasis doorways predicted worse outcomes in Black women with residual ER+/HER2– cancer after neoadjuvant...
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ASH 2022: New clinical data challenge long-held assumptions
Fresh research to be unveiled at the 2022 American Society of Hematology conference seems to overturn conventional wisdom across a range of issues...
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Poor NAFLD outcomes with increased VCTE-measured liver stiffness
The findings show that “progression to LSM-defined cirrhosis by VCTE is strongly associated with poor clinical outcomes.”
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New ACR vaccination guideline: Take your best shot
Vaccinate patients with rheumatic and musculoskeletal disease against flu and other vaccine-preventable disease whenever possible, experts say.
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Midodrine may be comparable to albumin for PICD prevention in ACLF
Given the small size of the open-label study, with only 25 patients in each arm, the results should be considered as proof of concept and need to...
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Randomized trial finds community-based weight-loss programs ease knee OA pain
Participants who dieted and exercised in a community-based randomized trial had reductions in knee pain at 18 months; controls also improved...
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Opioids increase risk for all-cause deaths in RA vs. NSAIDs
The incidence of all-cause mortality was higher for patients with rheumatoid arthritis who started on opioids rather than NSAIDs for pain control...
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Prednisone, colchicine equivalent in efficacy for CPP crystal arthritis
In an open-label, randomized trial, one in five patients on colchicine had diarrhea, tipping the safety scales in favor of prednisone.
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Steroids and G-CSF improve 90-day survival in severe alcoholic hepatitis
In addition to its superior results on the primary endpoint of 90-day survival, combination therapy was associated with significantly better...
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Retention rates high after biosimilar-to-biosimilar switch for inflammatory arthritis
Danish investigators studied how a government-mandated switch from one infliximab biosimilar to another affected patients with inflammatory...
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First recommendations for cancer screening in myositis issued
The guideline, based on data from a systematic review and meta-analysis and on consensus from an international team of experts and patients,...
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World falls short on HBV, HCV elimination targets
“As countries progress toward eliminating hepatitis B and C, we really need to do more to expand political will and financing of national...