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Resmetirom reduces liver, CV risk factors in NASH with cirrhosis
“I do think it could be one of the drugs that really improves outcomes for patients with NASH.”
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NAFLD progresses to cirrhosis in young and old at similar rate
Risk factors for NAFLD vary with age, but all patients experience similar progression of advanced disease once it develops.
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High-quality index colonoscopies pay off down the road for low-risk patients
Later risk for advanced adenomas, serrated polyps, or colorectal cancer was lower for patients with an initial high-quality colonoscopy.
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Easier bowel prep recipe yields real-world results
A reduced-volume bowel prep formulation was safe and was associated with high rates of adequate or better cleansing in a large practice-based...
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Some young CRC patients are missing out on genetic counseling, testing
Genetic counseling and testing of patients under 50 with CRC have improved over the last decade, but about 20% of patients still don’t get...
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EUS-guided RF ablation doubles survival for unresectable pancreatic cancer
Endoscopic ultrasound–guided radiofrequency ablation of tumors improved overall survival compared with standard of care.
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Mucus unplugged
Investigators seek balance between preserving mucus’s protective function and reducing oversecretion in inflammatory lung diseases.
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Sotorasib superior to docetaxel in KRAS G12C–mutated NSCLC
In its first randomized, phase 3 comparison trial, the first-in-class agent sotorasib held its own against the standard of care docetaxel.
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Obstructive sleep apnea linked to unprovoked VTE
People should be made aware of these links and try to make lifestyle changes to reduce their risk of OSA.
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Atezolizumab doubles survival of NSCLC patients with poor performance status
Patients typically excluded from clinical trials because of age or comorbidities had better survival with atezolizumab than single-agent...
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A farewell to arms? Drug approvals based on single-arm trials can be flawed
Objective responses, not time-dependent survival outcomes, should be endpoints for single-arm trials, with results only used for conditional...
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Lung volume reduction methods show similar results for emphysema
“Until now there had been no direct comparison of the two to inform decision-making.”
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Pembro/chemo combo fails to improve event-free survival in head and neck cancer
Some trends favored chemoradiation plus pembrolizumab over chemoradiation alone, but KEYNOTE-412 failed to meet primary endpoint.
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‘Smoking gun–level’ evidence found linking air pollution with lung cancer
The finding could lead to strategies for preventing lung cancer in nonsmokers exposed to high levels of foul air.
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Biomarker-guided steroid therapy shown safe for COPD
“A personalized endotype-based treatment with oral prednisolone is possible in patients with COPD.”