Key clinical point: Antioxidants show favorable efficacy and safety as an adjunct therapy for atopic dermatitis (AD), particularly when supplemented with oral vitamin D and topical vitamin B 12.
Major finding: Overall, antioxidants vs placebo were associated with a significant reduction in disease severity scores (P < .0001), with a significant decrease in AD severity observed for oral supplementation with vitamin D ( P = .01); combined vitamins D and E ( P = .003); combined vitamins A, D, and E ( P = .02); and topical vitamin B 12 ( P < .0001). No serious adverse events were reported.
Study details: Findings are from a meta-analysis of 18 studies including 763 patients with AD.
Disclosures: This study did not receive any funding. No conflict of interests was reported.
Source: Yang H et al. Efficacy and safety profile of antioxidants in the treatment of atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials. Dermatol Ther. 2022 (May 3). Doi: 10.1111/dth.15549