Individuals with inflammatory rheumatic diseases such as inflammatory arthritis, vasculitis, and connective tissue diseases, have a threefold increase in the risk of venous thromboembolism, compared with the general population, according to a meta-analysis.
The meta-analysis of 25 studies – 10 of which included patients with rheumatoid arthritis (RA) – found those with RA were more than twice as likely to develop deep vein thrombosis or a pulmonary embolism, compared with an age- and sex-matched individuals who had other comorbidities such as diabetes, peripheral vascular disease/coronary artery disease, and malignancy (OR, 2.23; 95% confidence interval, 2.02-2.47). The RA patients had a cumulative venous thromboembolism (VTE) incidence of 2.18% (Arthritis Res. Ther. 2014;16:435 [doi:10.1186/s13075-014-0435-y]).
Dr. Janet Pope
Ten studies comprising 54,697 patients with systemic lupus erythematosus showed a cumulative thrombosis incidence of 7.29% (95% CI, 5.82%-8.75%). Other diseases for which the investigators calculated cumulative incidence rates of VTE, based on four studies apiece, were Sjögren’s syndrome (2.18%; 95% CI, 0.79%-3.57%), inflammatory myositis (4.03%; 95% CI, 2.38%-5.67%), Antineutrophil cytoplasmic antibody vasculitis (7.97%; 95% CI, 5.67%-10.28%), and systemic sclerosis (3.13%; 95% CI, 1.73%-4.52%).
“We believe that the increased VTE risk is associated with the activity of the inflammatory diseases, rather than with the treatments used for controlling the disease,” wrote Dr. Jason Lee of the University of Western Ontario, London, and Dr. Janet Pope, of the division of rheumatology at St. Joseph’s Health Care, London, Ont.
The authors said that they had no conflicts of interest.