Key clinical point : Maintenance treatment with tyrosine kinase inhibitors (TKIs) following Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is safe and effective in patients with FLT3 mutated acute myeloid leukemia (AML).
Major finding : After a median follow-up of 10 months after allo-HSCT, 29 patients (71%) were alive and in complete remission (CR). In the subgroup of pretransplant TKI-treated patients, 25 patients (78%) were alive and in CR. 17 patients (41%) experienced side effects and 7 patients (17%) discontinued TKIs as a result of adverse events.
Study details : The data come from a retrospective observational study involving 41 patients treated with posttransplant TKIs (sorafenib, n = 23; midostaurin, n = 18). 32 patients (79%) had also received TKIs before allo-HSCT.
Disclosures: The authors declared no conflicts of interest.
Source: Shimony S et al. Leuk Lymphoma. 2021 Apr 21. doi: 10.1080/10428194.2021.1913145 .