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Decreased Prevalence of HPV High Grade Lesions
Am J Public Health; 2016 Dec; Flagg, et al
Prevalence decreases in high-grade lesions show their strong link with human papillomavirus types 16 and 18, and is evidence that the human papillomavirus vaccination is effective in young women, according to an analysis involving 9 million private insurance claims.
Participants were between 15 and 39 years of age. Investigators estimated annual prevalence of cytologically detected cervical low-grade (LSIL) and high-grade squamous intraepithelial lesions (HSIL) and high-grade histologically detected cervical intraepithelial neoplasia grades 2 and 3 (CIN2+) during an 8-year period ending in 2014. Among the results:
- HSIL and CIN2+ prevalence decreased significantly in 15- to 19-year-olds.
- Average annual percent change in HSIL prevalence in this group over 8 years was -8.3%; CIN2+ prevalence was −14.4% during this time.
- HSIL and CIN2+ prevalences also decreased significantly in women 20 to 24 years of age.
- No decreases were seen in women ≥25 years of age.
Flagg E, Torrone E, Weinstock H. Ecological association of human papillomavirus vaccination with cervical dysplasia prevalence in the United States, 2007-2014. Am J Public Health. 2016;106(12):2211-2218. doi:10.2105/AJPH.2016.303472.