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Peripheral T-Cell Lymphoma Diagnostic Work-Up Analyzed
Clin Lymphoma Myeloma Leuk; ePub 2017 Jan 10; Hsi, et al
Diagnostic workup for peripheral T-cell lymphomas (PTCL) varies widely in the US, according to an analysis involving nearly 435 individuals.
Using data from the COMPLETE study, investigators looked at the histopathological diagnosis approach for PTCL. Among the results:
- The most common diagnoses: PTCL-not otherwise specified (PTCL-NOS); anaplastic large cell lymphoma (ALCL); and angioimmunoblastic T-cell lymphoma (AITL).
- An average of 10 markers/patient were assessed.
- CD30 was assessed often but not in the same way across non-ALCL cases.
- Only 17% of PTCL-NOS cases were assessed for PD1.
- CXCL13 was a sensitive marker in AITL, expressed in 84% of tested cases; however, only 3% of PTCL-NOS cases were tested.
- For T follicular helper marker assessment, PD1 was evaluated in 6 in every 10 cases by academic centers, vs 1 in every 10 patients in community practices.
The authors pointed out the increasing importance of making accurate diagnosis given the emergence of targeted treatments.
Citation:
Hsi E, Horwitz S, Carson K, et al. Analysis of peripheral T-cell lymphoma diagnostic work-up in the United States. [Published online ahead of print January 10, 2017]. Clin Lymphoma Myeloma Leuk. doi:10.1016/j.clml.2016.10.001.