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Colony-Stimulating Factor Overuse in Lung Cancer Patients

J Oncol Pract; ePub 2017 Mar 4; Adeboyeje, et al

Use of a decision support tool seemed to improve risk-appropriate, guideline-adherent colony-stimulating factor (CSF) use in lung cancer patients, according to a retrospective cohort study involving nearly 3,500 individuals.

Participants—all of whom had lung cancer—were treated at oncology practices in 14 states. The states either did (n=1,150) or did not (n=974) implement the tool. Investigators evaluated both groups pre- and post-intervention, looking specifically at differences in CSF use and febrile neutropenia (FN) incidence. Among the results:

  • There were no differences in FN risk factors at baseline.
  • After adjusting for certain variables, CSF use decreased from 48% to 36% in intervention states; it rose from 43% to 44% in the nonintervention states.
  • FN rates were consistent for both groups during both periods.

Citation:

Adeboyeje G, Agiro A, Malin J, Fisch M, DeVries A. Reducing overuse of colony-stimulating factors in patients with lung cancer receiving chemotherapy: Evidence from a decision support–enabled program. [Published online ahead of print March 4, 2017]. J Oncol Pract. doi:10.1200/JOP.2017.020867.