Key clinical point: A set of single-nucleotide polymorphisms associated with increased bleeding risk were identified in African American patients on warfarin.

Major finding: Four single-nucleotide polymorphisms associated with increased bleeding risk were identified, including one seen in about one-third of bleeding cases and less than 5% of controls.

Study details: A genome-wide association study including a total of 71 African American patients with major bleeding on warfarin and 332 controls.

Disclosures: The investigators reported no conflicts of interest. Funding for the study came from the National Heart, Lung, and Blood Institute; National Institute of General Medicine, National Institutes of Health; the American Heart Association Midwest Affiliate; and the University of Illinois at Chicago College of Pharmacy.

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