Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Next-generation sequencing can shed light on neuropathy etiology

Publish date:: October 20, 2019

Key clinical point: Genetic testing may help identify the etiology of neuropathy in patients even with no family history.

Major finding: Next-generation sequencing demonstrated that 19% of patients with neuropathy tested positive for a pathogenic mutation.

Study details: The findings are based on next-generation genetic sequencing of 85 patients at the University of Pittsburgh Medical Center’s Neuromuscular Clinic.

Disclosures: No external funding was noted, and the authors had no disclosures.

Citation:

Zivkovic S et al. AANEM 2019. Abstract 160. Targeted genetic testing in the evaluation of neuropathy.

This Week's Must Reads

Younger adults present with more advanced esophageal adenocarcinoma,

Osteoporosis prevalence in PsA similar to general population,

Mortality risks rise with age, infections, but not inhibitor status in persons with non-severe hemophilia A,

DOACs look safe in elective endoscopic procedures,

Anorexia and diarrhea top list of GI symptoms in COVID-19 patients,

Must Reads in Neurology

HIT-6 may help track meaningful change in chronic migraine,

Vascular dementia risk particularly high in type 2 diabetes,

Low VWF levels or blood group O not linked to intracerebral hemorrhage risk,

Blood biomarkers could help predict when athletes recover from concussions,

Mortality burden of dementia may be greater than estimated,