Clinical Neuroscience

Lithium and kidney disease: Understand the risks

Author and Disclosure Information

 

References

Bottom Line

Lithium is an effective treatment for bipolar disorder, but its perceived irreversible nephrotoxic effects make some clinicians hesitant to prescribe it. Discontinuing lithium or switching to another medication also carries risks. For most patients who have been receiving lithium for a long time, the recommendation is to obtain a renal MRI and to cautiously continue lithium if the patient does not have microcysts.

Related Resources

  • Hayes JF, Osborn DPJ, Francis E, et al. Prediction of individuals at high risk of chronic kidney disease during treatment with lithium for bipolar disorder. BMC Med. 2021;19(1):99. doi: 10.1186/s12916-021-01964-z
  • Pelekanos M, Foo K. A resident’s guide to lithium. Current Psychiatry. 2021;20(4):e3-e7. doi:10.12788/cp.0113

Drug Brand Names

Lithium • Eskalith, Lithobid
Sirolimus • Rapamune
Valproate • Depacon

Pages

Recommended Reading

Reproductive safety of treatments for women with bipolar disorder
MDedge Psychiatry
Antidepressants, TMS, and the risk of affective switch in bipolar depression
MDedge Psychiatry
Steroid-induced psychiatric symptoms: What you need to know
MDedge Psychiatry
Contradictions abound in ‘The End of Mental Illness’
MDedge Psychiatry
Helping psychiatric patients heal holistically
MDedge Psychiatry
Tic disorders proliferate in bipolar patients with OCD
MDedge Psychiatry
Bright light therapy for bipolar depression: A review of 6 studies
MDedge Psychiatry
Novel drug offers rapid relief from agitation in serious mental illness
MDedge Psychiatry
Prevalence of psychiatric disorders higher in adult cerebral palsy patients
MDedge Psychiatry
APA, AMA, others move to stop insurer from overturning mental health claims ruling
MDedge Psychiatry