Key clinical point: Children and adults with atopic dermatitis may be at a greater risk of several major neuropsychiatric disorders.

Major finding: Compared with controls, after adjusting for age, gender, socioeconomic status, asthma, and allergic rhinitis, risks of bipolar disorder (hazard ratio, 1.34), obsessive-compulsive disorder (HR, 1.30), anxiety (HR, 1.09), and depression (HR, 1.06) were elevated among children and adolescents with atopic dermatitis; among adults, risks of autism (HR, 1.53), obsessive-compulsive disorder (HR, 1.49), ADHD (HR, 1.31), anxiety (HR, 1.17), depression (HR, 1.15), and bipolar disorder (HR, 1.12; 95% CI, 1.04-1.21) were elevated.

Study details: A population-based cohort study of 434,859 children and adolescents with atopic dermatitis matched to almost 2 million controls without atopic dermatitis, and 644,802 adults with atopic dermatitis matched to over 2.8 million adults without atopic dermatitis.

Disclosures: The study was funded by a grant from Pfizer. Dr. Wan reports receiving research funding from Pfizer paid to her institution.