Among overweight or obese adults with subsyndromal depressive symptoms, multinutrient supplementation compared with placebo and food-related behavioral activation therapy, compared with no therapy, did not reduce episodes of major depressive disorder (MDD) during 1 year, according to a recent study. This multicenter, 2 × 2 factorial, randomized clinical trial included overweight adults (BMI: 25-40) with elevated depressive symptoms and no MDD episode in the past 6 months. A total of 1,025 adults were randomized (July 30, 2015-October 12, 2016) and followed up for 1 year. Researchers found:

• Among total participants (mean age, 46.5 years; 772 women [75%]; mean BMI, 31.4), 779 (76%) completed the trial.
• During the 12-month follow-up, 105 (10%) developed MDD: 25 (9.7%) patients in the placebo without therapy, 26 (10.2%) in the placebo with therapy, 32 (12.5%) in the supplement without therapy, and 22 (8.6%) in the supplement with therapy group.
• None of the treatment strategies affected MDD onset.
• The odds ratio (OR) for supplements was 1.06; for therapy, 0.93; and for their combination, 0.93.