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Impact of Polygenic Risk Scores & Urbanicity in Schizophrenia

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The effect of genetic liability on risk of treatment-resistant schizophrenia (TRS) varies across urbanicity levels and was highest for those with schizophrenia born in capital areas, a new study found. The cohort study included individuals born after 1981 with a first registered diagnosis of schizophrenia between 1996-2012 using Danish population registry data. Researchers assessed urbanicity at birth. TRS was defined using prescription and hospital data. Among the findings:

  • Among 4,475 individuals with schizophrenia, 593 were identified with TRS during 17,558 person-years of follow-up.
  • The adjusted hazard ratio (aHR) for TRS associated with 1 standard deviation increase in the PRS-SZ was 1.11.
  • The aHRs for TRS across levels of urbanicity were 1.20 for rural areas compared with the capital area.
  • Within strata of urbanicity, the aHR for TRS was 1.39 in the capital area.

Citation:

Gasse C, et al. Schizophrenia polygenic risk scores, urbanicity and treatment-resistant schizophrenia. [Published online ahead of print August 22, 2019]. Schizophrenia Res. doi: 10.1016/j.schres.2019.08.008.

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