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Dupilumab relieves severe sinusitis with polyposis

Publish date:: February 25, 2019

Key clinical point: Dupilumab met its primary efficacy and safety endpoints in a pivotal trial for treating chronic sinusitis with nasal polyps.

Major finding: After 24 weeks, the endoscopic nasal polyp score averaged a clinically meaningful 2.06 points lower on dupilumab, compared with placebo.

Study details: SINUS-24, a multicenter randomized trial with 276 patients.

Disclosures: SINUS-24 was funded by Regeneron and Sanofi, the companies that market dupilumab (Dupixent). Dr. Han has been an adviser to Regeneron and Sanofi.

Citation:

Han JK et al. AAAAI, Abstract L4.