Key clinical point: Antihypertensive drugs do not exacerbate depression, but several specific agents appear to reduce risk of a mood disorder.

Major finding: Of 41 drugs, 2 of 16 angiotensin agents, 3 of 10 calcium-channel blockers, and 4 of 15 beta-blockers reduced depression risk.

Data source: A retrospective analysis of population-based registry.

Disclosures: The authors reported no potential conflicts of interest involving this topic.