Leukemia, Myelodysplasia, Transplantation
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Investigating the cause of infant leukemias
Results of whole-exome sequencing suggested that infants with leukemia inherited genetic variants from both parents that, by themselves, would not...
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Study reveals potential target for mucositis, GVHD prevention
Results of preclinical research point to a possible way of preventing mucositis, graft-vs-host disease, and other disorders associated with...
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CAR T-cell therapy: The good and the bad
Credit: MSKCC Several studies have shown that infusions of T cells modified with chimeric antigen receptors (CARs) can elicit complete responses...
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Inhibitor shows preclinical promise in leukemia, MM
Credit: VCU The experimental drug dinaciclib could potentially improve the treatment of multiple myeloma (MM) and myeloid leukemias, according to...
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Protein may be target for AML treatment
The protein WTAP could play an important role in the development of acute myeloid leukemia (AML), according to new research. Investigators...
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Omacetaxine mepesuccinate gets full FDA approval
Credit: Bill Branson The US Food and Drug Administration (FDA) has granted full approval of omacetaxine mepesuccinate (Synribo) for the treatment...
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Research clarifies role of Ikaros in B-ALL
Credit: Aaron Logan Two papers published in Nature Immunology have shed new light on the role of Ikaros in B-cell acute lymphoblastic leukemia (B...
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Making K-Ras cancers druggable
Credit: PNAS New findings suggest drugs can effectively fight K-Ras-mutant cancers—if they have a little help. Experiments in human cancer cells...
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Mutant HSCs appear to drive AML
These HSCs also appear to be a means of treatment resistance and may trigger relapse in patients with AML, investigators reported in Nature. “Our...
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New insight into megakaryocytic leukemias
Researchers have linked a mutation causing Down syndrome-associated leukemias to developmental abnormalities in megakaryocytes. Experiments...
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FDA approves ibrutinib for previously treated CLL
Credit: Rhoda Baer The US Food and Drug Administration (FDA) has expanded the indication for the Bruton’s tyrosine kinase inhibitor ibrutinib (...