Calls to US poison centers (PCs) indicate an increasing trend of naloxone use from 2000 to 2016, according to a recent analysis. The National Poison Data System (NPDS) was queried for cases reporting naloxone therapy from January 1, 2000, through December 31, 2016. Demographic and clinical characteristics were descriptively assessed. Trends in naloxone reports were evaluated by using generalized linear mixed models that were adjusted for age, gender and random effects of the geographical census region. Investigators found:

• There were 304,249 cases reporting naloxone therapy during the study period.
• The frequency of naloxone reports increased from 9,498 in 2000 to 26,826 in 2016.
• The proportion of cases where naloxone was used prior to PC recommendation increased from 59.8% in 2000 to 81.5% in 2016.
• The mean number of NPDS naloxone reports per 100,000 human exposures increased from 9.6 to 31.7.
• Among the cases, 52.4% were female and the most frequent age group was 20‐39 years (39.1%).
• The principal reason for a toxic exposure resulting in a naloxone report was suspected suicide (55.0%).
• Opioids (59.7% cases), were the most commonly reported exposure agents.