Key clinical point: Acne patients on isotretinoin may be more vulnerable to depression and suicide, but data show no causal relationship.

Major finding: Depression and anxiety were reported equally between sexes, but completed suicides (290 of 368 [78.8%]) were more common in males.

Study details: The data come from a retrospective study of reported psychiatric events potentially linked to isotretinoin.

Disclosures: Mr. Singer had no financial conflicts to disclose. Study coauthor John S. Barbieri, MD, disclosed partial salary support from Pfizer and grand support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Arash Mostaghimi, MD, disclosed personal fees from Pfizer.