Clinical Inquiries
Clinical Inquiries
What’s the best VTE treatment for patients with cancer?
EVIDENCE-BASED ANSWER: No head-to-head studies directly compare all the main treatments for venous thromboembolism (VTE) in cancer patients. Long-...
Clinical Inquiries
How effectively do ACE inhibitors and ARBs prevent migraines?
EVIDENCE-BASED ANSWER: The angiotensin-converting enzyme (ACE) inhibitor lisinopril reduces the number of migraines by about 1.5 per month in...
Clinical Inquiries
Do statins alter the risk or progression of dementia?
EVIDENCE-BASED SUMMARY: No. Moderate-intensity statin therapy (with pravastatin or simvastatin) doesn’t prevent progression to dementia in...
Clinical Inquiries
How often does long-term PPI therapy cause clinically significant hypomagnesemia?
EVIDENCE-BASED ANSWER: Rarely. Proton pump inhibitors (PPIs) may be associated with decreases in serum magnesium laboratory...
Clinical Inquiries
What’s the best secondary treatment for patients who fail initial triple therapy for H pylori?
EVIDENCE-BASED ANSWER: Treating patients with Helicobacter pylori infection who have failed clarithromycin-based triple therapy with either...
Clinical Inquiries
What are the benefits/risks of giving betamethasone to women at risk of late preterm labor?
EVIDENCE-BASED ANSWER: Giving betamethasone to women at risk for delivery between 34 weeks 0 days and 36 weeks 6 days can lower by almost 40% the...
Clinical Inquiries
Can CBT effectively treat adult insomnia disorder?
EVIDENCE-BASED ANSWER: Yes. Cognitive behavioral therapy (CBT) administered individually, in a group setting, or on the internet is effective for...
Clinical Inquiries
Does prophylactic azithromycin reduce the number of COPD exacerbations or hospitalizations?
EVIDENCE-BASED ANSWER: Yes for exacerbations, no for hospitalizations. Prophylactic azithromycin reduces the number of exacerbations by about 25...
Clinical Inquiries
How effective and safe is fecal microbial transplant in preventing C difficile recurrence?
EVIDENCE-BASED ANSWER: Fecal microbial transplant (FMT) is reasonably safe and effective. In patients who have had multiple Clostridium difficile...
Clinical Inquiries
Does niacin decrease cardiovascular morbidity and mortality in CVD patients?
EVIDENCE BASED ANSWER: No. Niacin doesn’t reduce cardiovascular disease (CVD) morbidity or mortality in patients with established disease (...
Clinical Inquiries
What are the benefits and risks of daily low-dose aspirin for primary prevention of CV events?
EVIDENCE-BASED ANSWER: One nonfatal myocardial infarction (MI) will be avoided for every 126 to 138 adults who take daily aspirin for 10 years (...