Clinical Inquiries
Clinical Inquiries
Which medications work best for menorrhagia?
EVIDENCE-BASED ANSWER: Four medications have been shown to reduce menstrual blood loss (MBL) significantly in placebo-controlled randomized...
Clinical Inquiries
Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS?
EVIDENCE-BASED ANSWER: No. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet medications such as clopidogrel for acute coronary...
Clinical Inquiries
Do cinnamon supplements improve glycemic control in adults with T2DM?
EVIDENCE-BASED ANSWER: The answer isn’t clear. Cinnamon supplements for adults with type 2 diabetes haven’t been shown to decrease hemoglobin A1C...
Clinical Inquiries
Does vitamin D supplementation reduce asthma exacerbations?
EVIDENCE-BASED ANSWER: Yes, to some extent it does, and primarily in patients with low vitamin D levels. Supplementation reduces asthma...
Clinical Inquiries
Do prophylactic antipyretics reduce vaccination-associated symptoms in children?
EVIDENCE-BASED ANSWER: Yes for acetaminophen, not so much for ibuprofen. Prophylactic acetaminophen reduces the odds of febrile reactions in the...
Clinical Inquiries
Does screening by primary care providers effectively detect melanoma and other skin cancers?
EVIDENCE-BASED ANSWER: Possibly. No trials have directly assessed detection of melanoma and other skin cancers by primary care providers.
Clinical Inquiries
What is the best treatment for wrist ganglion cysts?
EVIDENCE-BASED ANSWER: Open surgical excision of wrist ganglion cysts is associated with a lower recurrence rate than aspiration with or without...
Clinical Inquiries
Do group visits improve HbA1c more than individual visits in patients with T2DM?
EVIDENCE-BASED ANSWER: Yes. In patients with type 2 diabetes mellitus (T2DM), group visits led by health professionals or teams improved...
Clinical Inquiries
Does using e-cigarettes increase cigarette smoking in adolescents?
EVIDENCE-BASED ANSWER: Probably. Electronic cigarette (e-cigarette) use by adolescents is associated with a 2- to 4-fold increase in cigarette...
Clinical Inquiries
Does tranexamic acid reduce mortality in women with postpartum hemorrhage?
EVIDENCE-BASED ANSWER: Yes. When used in conjunction with the standard of care, 1 g intravenous (IV) tranexamic acid given 1 to 3 hours after...
Clinical Inquiries
Time to conception after miscarriage: How long to wait?
EVIDENCE-BASED ANSWER: An interpregnancy interval (IPI) of < 6 months following miscarriage is associated with an increased live birth rate in...