No cognitive or functional capacity benefit was determined from the implementation of a computerized cognitive training program in people with schizophrenia, a new study found. The 26-week randomized blinded placebo-controlled trial included 150 participants who were randomized to experimental or active control groups. Training was conducted in-clinic, with an intended training schedule of 5 days per week, 1 hour per day, for 26 weeks. Co-primary outcome measures were the MATRICS Consensus Cognitive Battery (MCCB) composite score and the UCSD Performance-Based Skills Assessment (UPSA-2) total score. Researchers found:

• The groups were well matched at baseline.
• No significant effect of the experimental treatment was observed on the primary or secondary outcome measures compared to the active control.
• Review of the task learning/target engagement data suggested inadequate engagement.