Key clinical point: Among Hispanic adolescents, sexual health interventions have a small but significant effect on improving safe sexual behavior. Cultural tailoring may contribute to a program’s success.

Major finding: Sexual health interventions improved abstinence (d = 0.15), condom use (d = 0.44), number of sex partners (d = –0.19), and sexual health knowledge (d = 0.40), compared with control conditions.

Study details: A meta-analysis of 12 studies with 4,673 participants.

Disclosures: The study authors had no relevant financial disclosures. The research was supported by the Doug Kirby Adolescent Sexual Health Research Grant from the Rural Center for AIDS and Sexually Transmitted Disease Prevention, Indiana University School of Public Health–Bloomington, and the Center for Family and Community Engagement, North Carolina State University.